How breast cancer spreads

ScienceDaily (Sep. 10, 2012) ? The invasion of cancer cells into the lymph vessels that connect the breast to surrounding lymph nodes is the first step leading to the metastasis, or spread, of cancer throughout the body. Metastasis is the primary cause of breast cancer deaths. Surprisingly little is known about the control of this process and how it might be interrupted to prolong the lives of women with breast cancer.

In a study to be reported Sept. 10 in the Proceedings of the National Academy of Sciences Online Early Edition, researchers at Johns Hopkins describe their discovery of how a protein responsible for cell survival in low oxygen can trigger the spread of cancer cells into the lymphatic system in a mouse model of breast cancer.

The researchers knew that like all solid tumor cancers, breast cancer cells can grow so densely that they end up starved for oxygen. To survive, cancer cells trigger the growth of new blood vessels by activating a protein called hypoxia-inducible factor 1, or HIF-1. "We've known that increased levels of HIF-1 are associated with increased tumor vessels and with patient mortality," says Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine, director of the vascular program at Hopkins' Institute for Cell Engineering and a member of the McKusick-Nathans Institute of Genetic Medicine. "Now we've found that HIF-1 activity is directly responsible for the spread of breast cancer to the lymph vessels."

Working in mice injected with human breast cancer cells, which when left undisturbed grow into tumors that spread from the breast to the lungs, Semenza's team previously found that interfering with HIF-1 in these mice reduced growth of the primary tumor and prevented metastasis through blood vessels to the lung. "So of course we wanted to see whether blocking HIF-1 could affect lymph node metastasis as well," he says.

In new experiments, they injected mice with human breast cancer cells that were genetically engineered to knock down HIF-1 protein levels and, after 24 days, examined the mouse lymph nodes to see if the human breast cancer cells had spread. They found that compared to mice whose HIF-1 levels were left undisturbed, lymph nodes with knocked-down HIF-1 contained 76 percent fewer human breast cancer cells, supporting the idea that HIF-1 is somehow involved in the spread of breast cancer to lymph nodes.

To better understand how HIF-1 triggers this to happen, Semenza's team then starved human breast cancer cells of oxygen to see which of the genes involved in the growth of lymphatic vessels might respond to HIF-1. They found that the platelet-derived growth factor B gene -- PDGF-B -- was five times more active when oxygen was lacking. A closer look at the DNA sequence around the PDGF-B gene showed regions of DNA known to be recognized and bound by the HIF-1 protein. They tested this in cells and found that, indeed, HIF-1 protein binds to the PDGF-B gene and turns it on.

The team then took a closer look at PDGF-B to find out how it works once the gene is turned on. They found that PDGF-B that is made by breast cancer cells is pumped out of the cell and stimulates the growth of lymph vessels.

Treating the mice with either digoxin, which blocks HIF-1 activity, or imatinib, a cancer drug, reduced tumor size by 78 percent and reduced lymph node metastasis by 94 percent, although the researchers emphasized that more work must be done to determine whether these drugs will be effective in treating breast cancer patients.

"We're very excited by these results, having shown for the first time that HIFs are directly involved in the lymphatic metastasis of breast cancer," says Semenza. "These results provide experimental support for breast cancer clinical trials that target HIF-1 or PDGF-B." The first study of digoxin in women with breast cancer at the Johns Hopkins Oncology Center will begin later this year.

This study was funded by grants from the American Cancer Society and the National Cancer Institute (U54-143868) and by funds from the Johns Hopkins Institute for Cell Engineering.

Authors on the paper are Luana Schito, Sergio Rey, Huafeng Zhang, Carment Chak-Lui Wong and Gregg Semenza of Johns Hopkins; Marco Tafani and Matteo Russo of Sapienza University of Rome, Rome, Italy; and Andrea Russo of Istituti Fisioterapici Ospitalieri, Rome, Italy.

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The above story is reprinted from materials provided by Johns Hopkins Medicine, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Luana Schito, Sergio Rey, Marco Tafani, Huafeng Zhang, Carmen Chak-Lui Wong, Andrea Russo, Matteo A. Russo, and Gregg L. Semenza. Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells. PNAS, September 10, 2012 DOI: 10.1073/pnas.1214019109

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/UajUJbm6F1U/120910151052.htm

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Offlinebloodsheen
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Is it just me or is this quite possibly the dumbest concept in the entire world. Everyone's love is conditional! If you are married there are tons of conditions. You have to:

Pay attention to your partner
Not beat them/assault them
Not fuck other people
Contribute to the household in one way or another
Not kill other people at random
Not molest the neighbors daughter

And the list goes on. In fact, I would say that if you actually practice unconditional love you are an idiot. Why should anybody deserve unconditional love? If you are a horrible person or a worthless human being, you deserve to be treated appropriately. Whoever keeps perpetuating this idea needs to be stopped

--------------------
A cautious young fellow named Lodge / Had seat belts installed in his Dodge. / When his date was strapped in / He committed a sin / Without even leaving the garage. That's clever, isn't it?-A boy and his dog

Offlinekeyohnah
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The only time I buy unconditional love is with parents and that's not every single one by a far shot.

--------------------
"Go placidly amid the noise and haste, and remember what peace there may be in silence. As far as possible, without surrender, be on good terms with all persons. Speak your truth quietly and clearly; and listen to others, even to the dull and the ignorant, they too have their story."

InvisiblesadsappysuckerS
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You must be pretty fucked up if you have to tell yourself not to molest your neighbors kids nor beat, assault or kill others, let alone your partner. Sounds like you can use some love, any love, yourself.

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Onlinejoe666
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That's not love, that's decency.

Love is a deep emotional feeling of affection towards someone.

--------------------
"A politician is like a baby's diaper, it should be changed often and for the same reason"-Coy Turner Sr.

"what is a weed, a plant whose virtues have not yet been discovered"--Ralph Waldo Emerson

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OfflineShroomerited
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Quote:

bloodsheen said:
Is it just me or is this quite possibly the dumbest concept in the entire world. Everyone's love is conditional! If you are married there are tons of conditions. You have to:

Pay attention to your partner
Not beat them/assault them
Not fuck other people
Contribute to the household in one way or another
Not kill other people at random
Not molest the neighbors daughter

And the list goes on. In fact, I would say that if you actually practice unconditional love you are an idiot. Why should anybody deserve unconditional love? If you are a horrible person or a worthless human being, you deserve to be treated appropriately. Whoever keeps perpetuating this idea needs to be stopped



Definitely agree. Agreed so much.
Offlinebloodsheen
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Quote:

sadsappysucker said:
You must be pretty fucked up if you have to tell yourself not to molest your neighbors kids nor beat, assault or kill others, let alone your partner. Sounds like you can use some love, any love, yourself.

Lol, I wasn't suggesting I want to do those things at all. And this wasn't a "mommy doesn't love me thread." Its just as it is stated.

--------------------
A cautious young fellow named Lodge / Had seat belts installed in his Dodge. / When his date was strapped in / He committed a sin / Without even leaving the garage. That's clever, isn't it?-A boy and his dog

Offlinelifeiswhatyoumake
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Unconditional love is what humanity needs to work on, badly.

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Life is what you make of it.

OfflineLynnch
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Unconditional love doesn't mean you have to accept someone being a total dick, it means that even when they're being a dick you keep trying to help them.

OnlineAlphaFalfa
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It means that you see them as products of their environment.

You can't love someone for being something bad or good, you merely prefer their company.

You can love everyone but you need to somehow accept, realize that everyone's actions, thoughts and feelings are an outcome of the way their environment has influenced that.

--------------------
if you ever feel lost, just remember, life is not a journey, it is entertainment, all 4 fun...

OnlineAlphaFalfa
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Hate isn't wrong; its a waste of time because it doesn't grasp the true source of your problems with those you hate.

Our society hates criminals FOR EXAMPLE, but in reality these people are simply not being taken care of properly and/or their needs haven't been identified properly. They may have special needs for example but appear normal, until they snap and kill everyone.

When we hate others, were not seeing the solution to our hate, we are simply living in a vile and nasty emotion that is utterly useless and unproductive.

--------------------
if you ever feel lost, just remember, life is not a journey, it is entertainment, all 4 fun...

Offlinebloodsheen
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Ok, I must be the worst thread starter ever because my threads never seem to start the kinds of discussions I intend.

I wasn't talking about hate versus love. I agree, you shouldn't hate people, its a waste of time. But that doesn't mean you have to let somebody keep fucking up your life.

For instance, if you kid is an addict it isn't your duty to, year after year after year, put up with him stealing your money and stuff, verbally and physically assaulting your family members, and generally causing strife and heartache. You might say "I still love him/her" but in reality what you love is your perception of the person you believe they are capable of being.

If somebody is a cheater you shouldn't keep putting up with their behavior. And after 5 or 6 times catching them cheating, you are an idiot to continue to put up with it. Again, you don't truly love them, you love who you want them to be.

--------------------
A cautious young fellow named Lodge / Had seat belts installed in his Dodge. / When his date was strapped in / He committed a sin / Without even leaving the garage. That's clever, isn't it?-A boy and his dog

Offlinelifeiswhatyoumake
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Your first post in this thread was a bit "ehh."

But now we're chuggin'.

That is a tough example, the mom and drug-addict son.? You might not expect to hear what I'm gonna hear.?

In this situation, a real unconditionally loving mother would always be there for her son, drug-addict or not.? She has to show him love.? SHE HAS TO.? It's quite possibly the only way for her son to stop being an addict.? She has to show him that she really cares, but doesn't like her son's addiction.

If the son keeps stealing from his own mother for years... then I wouldn't want to find out where he goes when he dies.?

And to the cheating thing... 5/6 times???? wadafuq???? ONE TIME.? THAT'S ALL THEY HAVE.

--------------------
Life is what you make of it.

OfflineHeroMike
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Quote:

[
And to the cheating thing... 5/6 times???? wadafuq???? ONE TIME.? THAT'S ALL THEY HAVE.

QFT

Really though I think he's just making an example . If he said 1 , someone would have said why not 5/6 ya feel me?

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Offlinelifeiswhatyoumake
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Ah, you are right!? Thanks for the clarification.

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Life is what you make of it.

Offlinekeyohnah
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Quote:

bloodsheen said:

For instance, if you kid is an addict it isn't your duty to, year after year after year, put up with him stealing your money and stuff, verbally and physically assaulting your family members, and generally causing strife and heartache. You might say "I still love him/her" but in reality what you love is your perception of the person you believe they are capable of being.

If somebody is a cheater you shouldn't keep putting up with their behavior. And after 5 or 6 times catching them cheating, you are an idiot to continue to put up with it. Again, you don't truly love them, you love who you want them to be.


I definitely agree with the idea of loving who you wish the person was instead of actually loving the person who is now. I think that is more often the case than not.

I do, however, believe that there are occurrences of unconditional love. Let's take that mother you're talking about. She may wish her son was the way he used to be but she could still love him. That love is unconditional -- her LIKING her son is not. As my mother used to say, "I'll always love you but I sure as hell don't like you right now."

I don't believe all parents have this type of unconditional love but I do believe some, if not most, do. I think you can still love someone if you don't like them, regardless of what they've done to you or even if you've cut them out of your life. I don't think I have the capacity for that -- not now, as I sit here typing this. Maybe it'd change if I had a child but who knows.

--------------------
"Go placidly amid the noise and haste, and remember what peace there may be in silence. As far as possible, without surrender, be on good terms with all persons. Speak your truth quietly and clearly; and listen to others, even to the dull and the ignorant, they too have their story."

OfflineLynnch
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I think overall your point is correct, but really just indicates how rare true unconditional love is. If people didn't love the person they wish their partner was, they would break up at the first sign of a fight.
Always giving in to your addict son or always forgiving a cheater aren't examples of unconditional love, they're just examples of unhealthy love.
Unconditional love is saying 'I don't care how many trips to rehab it takes, I believe you can get better' or even 'I love you so much I think we should break up'. Nobody said love was the easy choice.

Offlinebloodsheen
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Quote:

Lynnch said:
Always giving in to your addict son or always forgiving a cheater aren't examples of unconditional love, they're just examples of unhealthy love.
Unconditional love is saying 'I don't care how many trips to rehab it takes, I believe you can get better' or even 'I love you so much I think we should break up'. Nobody said love was the easy choice.

Hm, but many addicts essentially guilt you into helping them get drugs. Especially when they arent illegal drugs i.e. alcoholics and pill poppers. So it comes to a point where you have to cut them off, and cutting them off is likely the same thing has kicking them out of your house.

And I'm not sure I understand what you mean by 'I love you so much I think we should break up.' How is breaking up with them because they are destroying your life any different than breaking up with them because you don't love the person they are? If you've come to the conclusion they can't be helped by you, you are essentially saying you don't love who they are anymore, and if they change and become something you are willing to love, they can come back. I.e. not unconditional love

--------------------
A cautious young fellow named Lodge / Had seat belts installed in his Dodge. / When his date was strapped in / He committed a sin / Without even leaving the garage. That's clever, isn't it?-A boy and his dog

Offlinekeyohnah
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Oh, I'm not trying to imply that unconditional love means putting up or tolerating someone's addiction. You are right that if someone is doing that it becomes an unhealthy love or enabling. I'm just trying to say that a mother can completely cut her addict son out of her life but still love them, even who they became. Unconditional love exists (though rarely) but I don't believe that unconditional "liking" exists.

--------------------
"Go placidly amid the noise and haste, and remember what peace there may be in silence. As far as possible, without surrender, be on good terms with all persons. Speak your truth quietly and clearly; and listen to others, even to the dull and the ignorant, they too have their story."

Offlinekeyohnah
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You can still love them even if you don't like their current actions.
Quote:

bloodsheen said:

And I'm not sure I understand what you mean by 'I love you so much I think we should break up.' How is breaking up with them because they are destroying your life any different than breaking up with them because you don't love the person they are? If you've come to the conclusion they can't be helped by you, you are essentially saying you don't love who they are anymore, and if they change and become something you are willing to love, they can come back. I.e. not unconditional love


The relationship has conditions-- not the love. You can still unconditionally love the person you broke up with but the relationship isn't unconditional.

--------------------
"Go placidly amid the noise and haste, and remember what peace there may be in silence. As far as possible, without surrender, be on good terms with all persons. Speak your truth quietly and clearly; and listen to others, even to the dull and the ignorant, they too have their story."

InvisibleSillyMe
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I have two kids and I love them unconditionally. They are of my flesh - there is nothing they could do that would stop me from loving them. I can't imagine getting to a point of not liking them even. For me I think it would be more a matter of being disappointed in their behavior/choices if they did something horribly wrong but I'd still like/love them. Always.

--------------------
I'm sorry for things I cannot even mention...

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Rally lifts stocks back to pre-recession levels

NEW YORK (AP) ? The last time the stock market was this high, the Great Recession had just started, and stocks were pointed toward a headlong descent.

But on Thursday, the market moved swiftly in the other direction. The Dow Jones industrial average hit its highest mark since December 2007, and the Standard & Poor's 500 index soared to its highest level since January 2008 in a rally that seemed destined to mark a milestone: American stocks have come almost all the way back.

A long-anticipated plan to support struggling countries in the European Union provided the necessary jolt, and the gains were extraordinarily broad. All but 13 stocks in the S&P index were up. European markets surged, too.

"There's just a sea of green," said JJ Kinahan, TD Ameritrade's chief derivatives strategist. "It's pretty fun."

At the start of 2008, the U.S. economy was already a month into recession, though most people scarcely knew it at the time. The S&P had recently hit an all-time high, and the unemployment rate was 5 percent, compared with the current 8.3 percent.

Then, in March 2008, the investment bank Bear Stearns collapsed under the weight of bad mortgage bets, and investors began to sell. In September, the full financial crisis took hold as Lehman Brothers filed for bankruptcy, banks stopped lending to each other and investors began dumping stocks in earnest.

By March 2009, the S&P had dropped 57 percent from its high to hit a 12-year low of 676.

Since then, the index has been on an impressive if often bumpy climb. Helping to power it was unprecedented support from the Federal Reserve, which critics say has reignited a dangerous gambling spirit among professional investors, and record profits at big U.S. companies.

Although stocks have rebounded, the broader economy is still lagging. But Barry Knapp, head of U.S. equity strategy at Barclays Capital, said stocks tend to anticipate the future economy rather than reflecting current conditions. So the signs are good.

"It can be a misleading forecasting tool, but sometimes it's telling you something significant," he said. "It's entirely possible the stock market is telling us that there is a better economic environment out there."

So could the rally help President Obama? A number of recent studies have connected a rising stock market to improved odds of re-election for the incumbent president. Since 1900, when the S&P 500 has posted gains from July to October in an election year, voters returned the sitting president to the White House 80 percent of the time, according to a study by S&P Capital IQ.

But no modern president has faced re-election when unemployment was so high. President Jimmy Carter was bounced from office in 1980 when unemployment was 7.5 percent.

If you started off 2008 by putting $10,000 in the S&P 500, the benchmark for most stock funds, you would now have $10,600, thanks to dividends. That's assuming you could stomach the ride. Your initial investment fell to $9,840 six months later, then plunged to $6,300 by the following January.

Starting in 2010, companies began generating higher and higher profits despite an anemic U.S. economic recovery. In fact, companies in the S&P 500 increased net income by double-digit percentages over eight quarters in a row through the end of last year ? a stretch that has surprised even Wall Street stock analysts, who are normally criticized for being too optimistic.

The way companies achieved that is familiar to any of the millions of Americans who've lost a job in recent years: Businesses cut workers, used technology to run more efficiently, slashed spending and squeezed remaining staff.

Sales to faster-growing countries in Asia also helped. Companies in the S&P 500 now generate 30 percent of their sales from overseas, Knapp said.

The market's rise did hit a few roadblocks, however, most notably in the summer of 2011, when Congress was squabbling over raising debt limits and fear was mounting that the U.S. could be headed into another recession.

Over one four-day stretch in August, the Dow rose or fell by 400 points each day, the first time that has happened. The S&P 500 ended flat for 2011.

Then earnings rose again this year, fears over European debt crisis receded and stocks soared again. For the first three months of 2012, the Dow was up 8 percent and the S&P 12 percent, in each case the best start since the great bull market of the 1990s.

The question now is whether big companies can continue to post record profits. The immediate outlook has no shortage of potential obstacles.

The U.S. economy grew a tepid 1.7 percent in the April-June period, less than half the pace of late last year. Big overseas economies, like Brazil's and China's, are slowing. And many countries in the 17-nation eurozone are in recession.

On Thursday, the chief economist of the Organization of Economic Cooperation and Development said he expects even powerhouse Germany to fall into recession by the end of the year.

As if that's not bad enough, the dollar has strengthened against major currencies recently. That makes U.S. products sold in foreign currencies more expensive, cutting into overseas revenue.

Thursday's rally got momentum after the president of the European Central Bank unveiled a new program to buy government bonds from the region's struggling countries with the aim of lowering their borrowing costs. Mario Draghi said the program will have no set limit on how much it can buy.

That was just what investors needed to hear. The S&P 500 index jumped 28.68 points to 1,432.12. The Dow Jones industrial average surged 244.52 points to 13,292.

The Nasdaq composite index also reach a milestone, gaining 66.54 points to close at 3,135.81, its highest level in 12 years.

Germany's DAX and France's CAC-40 each rallied 3 percent. The gains were even bigger in Spain and Italy, the two largest countries to become caught up in the region's long-running government debt crisis. Spain's benchmark index soared 5 percent, Italy's 4 percent.

Traders shifted money out of U.S. Treasury bonds, considered one of the world's safest places to stash money, and the drop in demand lifted yields. The yield on the 10-year Treasury note rose to 1.67 percent, up from 1.60 percent late Wednesday.

In an encouraging sign for the American job market, a report from the payroll processor ADP said businesses added 201,000 jobs last month, the most reported by the survey since March.

Separately, the Labor Department said the number of people applying for unemployment benefits fell by 12,000 last week to 365,000. That figure won't affect the August jobs report, due out Friday, but could be a sign of a better hiring this month.

Even before Thursday's surge, the stock rally has been one for the record books.

Jim Paulsen, chief investment strategist at Wells Fargo Capital Management, published a report last month showing that stock prices have more than doubled in the 3 ? years since hitting a recessionary low in March 2009. That surpasses every post-World War II rally after a recession over a similar period.

"We've been told from the start that this stock market was going to be low return and high risk, but it's turned out to be the best ever," Paulsen said Thursday. "Fear was way overdone."

Source: http://news.yahoo.com/rally-lifts-stocks-back-pre-recession-levels-214517203--business.html

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Blue Ivy Carter Photos: On a Boat With Jay-Z!


Jay-Z, Beyonce and Blue Ivy Carter are vacationing on a yacht on the Mediterranean Sea this week, celebrating Bey's 31st birthday (or just being really rich).

Candid Blue Ivy pictures are not exactly a dime a dozen - the couple is quite private, unlike say anyone with the last name Kardashian - so this is a rarity.

The little girl has no idea how good she has it, jet-setting in the South of France before age one. On the flip side, Jay and Bey seem like grounded parents.

Check out these cute shots of father and daughter:

Jay-Z and Blue IvyJay-Z and Blue Ivy CarterJay-Z, Blue Ivy Carter

[Photos: Fame/Flynet]

Source: http://www.thehollywoodgossip.com/2012/09/blue-ivy-carter-on-a-boat-with-jay-z/

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Lufthansa apologizes for strike disruption

BERLIN (AP) ? Lufthansa is apologizing to customers ahead of time for the widespread disruption expected Friday during a 24-hour walkout by flight attendants.

Still the German airline is making it clear it's up to the union to return to negotiations.

Lufthansa has canceled about 1,200 flights Friday, two-thirds of its schedule. Ads in several German newspapers on Thursday said: "We regret this very much and apologize for it."

The airline added: "We consider this strike disproportionate."

On Tuesday, several-hour walkouts by Lufthansa cabin crews in Frankfurt, Munich and Berlin caused about 350 flight cancelations.

Lufthansa and the UFO union are at odds over pay and conditions as the airline struggles with increasingly tough competition from European budget carriers and government-owned Gulf airlines. Lufthansa underlined hopes of "more competitive structures in future."

Source: http://news.yahoo.com/lufthansa-apologizes-strike-disruption-103743551.html

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How much is Honey Boo Boo's family paid?

Chris Fraticelli. / TLC

Alana "Honey Boo Boo" Thompson.

By Leslie Bruce, The Hollywood Reporter

Alana Thompson, the 7-year-old star of TLC's surprise hit "Here Comes Honey Boo Boo," raised eyebrows by announcing that "a dollar makes me holler."

PHOTOS: Broadcast TV's returning shows for 2012-13 season

But what would $40,000 make her do? Apparently, just about anything. The series follows the outspoken pageant contestant -- a breakout from the network's popular docuseries "Toddlers & Tiaras" -- and her family through the world of child beauty contests and their self-proclaimed "redneck" life in McIntyre, Ga.

When Thompson's "Toddlers" interview containing her reference to "Honey Boo Boo Child" went viral this year (the clip has more than 4.5 million views on YouTube), the cable network offered the "beauty queen" and her family their own spinoff series.

Kelly Clarkson's 'American Idol' victory, 10 years later

Sources told THR that the family of six (which recently expanded when Thompson's older sister, 18-year-old Anna Shannon, gave birth to daughter Kaitlyn on July 26) earns merely between $2,000 and $4,000 an episode -- possibly seeing as much as $40,000 for the 10-episode debut season. (A small "location fee" might also be paid to film in the family home.)

STORY: 'Honey Boo Boo' ratings top the Republican National Convention

TLC's modest investment in the Thompsons has turned out to be lucrative. The series scored nearly 3 million viewers for its Aug. 29 installment (which followed the family at a water park) -- up 30 percent from the previous week and topping every network's coverage of the Republican National Convention. A TLC rep says the network does not comment on salaries.

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Source: http://theclicker.today.com/_news/2012/09/05/13678910-how-much-money-are-the-stars-of-tlcs-honey-boo-boo-making?lite

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Syria slams Egyptian leader's speech as interference

BEIRUT (Reuters) - Syria condemned on Thursday calls by Egypt's president for change in the country, which is battling a 17-month-old uprising against Bashar al-Assad, saying they amounted to blatant interference in its internal affairs.

The foreign ministry said President Mohamed Mursi's comments to a meeting of Arab ministers in Cairo were a "clear attack on the right of the Syrian people to choose their future by themselves, without foreign interference".

"What Mursi said is media incitement which aims to fuel the violence in Syria. This is no different from other governments who support the armed terrorist groups with money and weapons and training and shelter, making them partners in Syria's bloodshed," the foreign ministry statement said.

Egypt's new Islamist president said on Wednesday the time had come in Syria "for change and not wasting time speaking of reform". In a speech which also touched on the revolt in Egypt, he said Syrian authorities "must take into account the lessons of recent and ancient history".

Mursi, who was the once-banned Muslim Brotherhood's candidate in the election which followed the overthrow last year of Hosni Mubarak, formally resigned from the group when he won the presidency in June. Syria's Brotherhood has been a major element in the revolt against President Assad.

The Syrian statement said Mursi's comments reflected "the views of a group that has no grasp of the history shared by the Egyptian and Syrian people".

(Reporting by Dominic Evans; Editing by Louise Ireland)

Source: http://news.yahoo.com/syria-slams-egyptian-leaders-speech-interference-123257217.html

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Legitimate Paid Surveys ? Get Paid For Every single Survey ...

Undoubtedly, on the internet jobs are one of the best means to earn extra cash. You can earn great sum without even leaving home or even dealing with a rude manager. An excellent net link is the only excellent requirement to begin with this task. One of the best online work includes paid surveys. There are lots of review websites and it can be rather tricky to choose any legitimate one. Moreover, take notice that Internet is loaded with lots of space pertaining to deception. Experts think that 40% of these websites are not more than fraudulent business schemes. In order to identify the legitimacy of a particular website, you should take into consideration a wide variety of aspects.

To begin with, get paid for your opinion do not ask for registration fees. Mostly, they are available for free. Secondly, this kind of websites pay close to $1 to $10 for each questionnaire that is submitted or taken. If the web site screams $60 per several hours than it may be a lie. In addition, check for corporation?s privacy policy. Click on the connect to ensure that it works. Also, ensure that a company is not purchased client data for any third party. Next, examine company information like email address and contact number carefully. Expert?s advice to call a particular company ahead of joining so as to ensure that the number really works.

A few of the examples of reliable internet sites include worldwide examination marketplace, survey for money, free surveys analysis and survey head. These websites do not fee any kind of registration charge for joining and so they send mail soon after receiving client data. So ensure that you mail correct mail handle while signing up. Additionally, check mail frequently at times survey announcements may expire. Paid surveys can help one earn a great sum of money. They can even support compensate those additional small time plans might know about make for family or perhaps ourselves.

Normally, online paid surveys take less than Half an hour to complete and this will help you earn from $3 to $50. Take into account; this is just perfect when you can shell out few hours each day so as to complete these. Depending upon the amount of time you adopt, there are also chances with regard to group discussions. Class discussions may take greater timespan but the rewards are generally higher to a significant extent. At times, companies pay around $90 let?s start for 2 or 3 hours discussions. If, you love interactions and speaking then this can prove for an excellent opportunity for a person.

In case of paid surveys, there are merely simple rules to follow. The rules of online with free streaming paid surveys are trouble free. You will find sites which provide total directories or provides of firms that present online surveys. These websites experienced the difficulty of studying on firms to provide surveys takers a complete report on the ones which are many trustworthy with high pays off. Importantly, do not think about these surveys are the main source of income. Do not depart your paying project for this one.

For more information about money for surveys please visit the website.

Source: http://www.welcometocoastcity.org/legitimate-paid-surveys-get-paid-for-every-single-survey.php

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Romney sequestered in Vermont for debate prep

WEST WINDSOR, Vt. (AP) ? Obama-Biden signs dot the back roads of Vermont, a state that has voted for a Democratic president since 1988. And yet, Republican presidential candidate Mitt Romney has chosen a friend's home in rural Vermont to hunker down to prepare for next month's presidential debates.

Presidential candidates in the past have chosen their homes or battleground states for debate preparation. Not Romney ? and his timing is unusual, too. Candidates usually spend the week of Labor Day campaigning heavily in battleground states.

Romney is staying largely out of the spotlight as President Barack Obama and the Democratic Party hold their convention in Charlotte, N.C.

Romney's advisers say he was looking for the distraction-free quiet of Vermont's Green Mountains. He's practicing at the mansion of former Massachusetts Lt. Gov. Kerry Healey.

Source: http://news.yahoo.com/romney-sequestered-vermont-debate-prep-223916325--election.html

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